In the human genome, genetic information is carried on two copies (two chromosomes), each copy being inherited from one of the parents. For most genes,…
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Small-interfering RNA (siRNA)-based therapeutics work by suppressing disease-causing genes, and they hold tremendous promise for targeting a large part of currently undruggable diseases, ranging from viral…
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We are what we eat. Human health is facing challenges from lifestyle diseases such as diabetes and obesity. A sedentary lifestyle coupled with a lack…
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TNF is an important mediator that drives the pathogenesis of several inflammatory auto-immune diseases, including Crohn’s Disease and rheumatoid arthritis (RA). Treatment of these diseases…
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National data show the high prevalence of multiple chronic conditions (MCCs) among the aging population. Almost half of community-dwelling people aged 45-64 and 80% of…
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The secreted immune factor, Tumor necrosis factor alpha (TNF-α), is an important inflammatory mediator that helps neutralize and destroy infectious agents as well as cancer…
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Excessive consumption of ethanol, the intoxicating agent in alcoholic drinks, and the ingestion of heavy metals in contaminated foods and drinks are known to lead…
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Neuroblastoma is the most common solid tumor of early childhood and arises from the primitive cells of the sympathetic nervous system. The survival rates for…
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Our planet has a self-regulating ecosystem that stabilizes the temperature, climate, and other external environments. Water covers more than 70% of the land surface, and…
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The aryl hydrocarbon receptor (AHR) was originally found in 1976 as the mediator of toxicity and induction of drug-metabolizing enzymes caused by the highly potent…
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Nerve cells have long processes that connect one cell to the other, orchestrating nerve-cell networks and allowing the brain to function. A major brain protein…
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