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Meta-Sulfamoyl N-Hydroxybenzamides As HDAC8-Selective Inhibitors

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As a family of epigenetic enzymes, histone deacetylases (HDACs) can catalyze the removal of an acetyl group from N-acetyl lysine residues of histones and other…
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Current Knowledge Of Lepidoptera Genomes And Future Directions

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Science is often advanced with the development of new technologies. Since the sequencing of the first human genome, there has been much progress made in…
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The Inactive X Chromosome Is Folded Like Origami By SMCHD1

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The linear molecules of DNA that constitute our genome are wrapped around proteins called histones to form “chromatin.” To fit the nucleus, chromatin must be…
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Lead Iodide Nanosheets For Piezoelectric Energy Conversion And Strain Sensing

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Harvesting ambient mechanical energy or sensing the mechanical signals based on nanomaterials for self-powered and flexible systems can provide potentially revolutionary advancements in energy technologies….
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Racial Disparity In Surgery For Esophageal Cancer

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Surgery for esophageal cancer (esophagectomy) is considered standard of care for patients with early-stage disease and can provide long-term survival benefits to the patients. These…
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Adverse Events Following Coronary Angiography And Cardiac Surgery

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Having a major adverse renal or cardiac event (MARCE) is a calculable risk following cardiac surgery. As techniques for percutaneous coronary interventions (PCI) have improved…
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Measuring The Water And Energy In An Alpine Peatland

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Peatlands are wetlands with at least a 30-40 cm thick peat layer and are highly dependent on water. In these waterlogged, anaerobic soils, the dead…
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Concentric Crater Fill: How Martian Craters Filled With Ice And Why It’s Still There

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Many mid-latitude impact craters on Mars are filled to variable degrees with a combination of ice, dust, and rocky debris. Ring-shaped surface features visible in…
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The Use Of Mobile Health (mHealth) For Increasing Physical Activity And Fitness In Cardiovascular Disease Populations

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Coronary artery disease (CAD) and peripheral artery disease (PAD) are diseases of atherosclerosis that have enormous clinical and economic burden in the United States. Adherence…
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Why We Get Frail And How To Reverse It

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Aging is characterized by a gradual loss of cellular homeostasis and tissue function. This is a major cause of frailty in the elderly, which reduces their quality…
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Exploring The Moon’s Iron Distribution

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The moon is considered to have experienced a magma ocean, with whole-body melting. Differentiation and crystallization of the melt formed today’s crustal Moon. Major elemental…
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