How Ethanol And Heavy Metals In Alcohol Sachets Are Affecting Uganda’s Acoli People

Excessive consumption of ethanol, the intoxicating agent in alcoholic drinks, and the ingestion of heavy metals in contaminated foods and drinks are known to lead to all kinds of illnesses. In the Acoli community of northern Uganda, heavy alcohol consumption, which became an adaptive mechanism for coping with trauma, depression, idleness, violence, hopelessness, and deprivation of

Optimizing Aging With Multiple Chronic Conditions

National data show the high prevalence of multiple chronic conditions (MCCs) among the aging population. Almost half of community-dwelling people aged 45-64 and 80% of those aged 65+ live with MCCs (Gerteis et al., 2014), and more than 2/3 of Medicare beneficiaries have MCCs (Centers for Medicare and Medicaid Services, 2012). The two national reports

TNF Concentrations During TNF Inhibitor Treatment Predict Anti-drug Antibody Formation

TNF is an important mediator that drives the pathogenesis of several inflammatory auto-immune diseases, including Crohn’s Disease and rheumatoid arthritis (RA). Treatment of these diseases has significantly improved since the introduction of therapeutic monoclonal antibodies that specifically target TNF (TNF inhibitors). Adalimumab is one of the five TNF inhibitors that is widely used in the

The Ancient Grain “Teff” To Manage Weight And Glucose

We are what we eat. Human health is facing challenges from lifestyle diseases such as diabetes and obesity. A sedentary lifestyle coupled with a lack of physical activity together with unhealthy diet habits (e.g., intake of sugary/energy drinks, extra salt, and sugar) is becoming a big threat to leading a healthy life. In ancient times,

A Brush Polymer Platform For Wider siRNA Application

Small-interfering RNA (siRNA)-based therapeutics work by suppressing disease-causing genes, and they hold tremendous promise for targeting a large part of currently undruggable diseases, ranging from viral infections to hereditary disorders and cancers.1 A Nobel prize was awarded to the discovery of RNA interference in 2006. However, the majority of the siRNA-based drug candidates having entered clinical trials

Revealing The Reasons Behind Clinical Resemblances Among Patients With Different Imprinting Disorders Leading To Growth Restriction

In the human genome, genetic information is carried on two copies (two chromosomes), each copy being inherited from one of the parents. For most genes, both copies (maternal and paternal) are expressed equally. However, it has been shown that ~150 human genes have been expressed from either the paternal or the maternal chromosome but not

A Look Into The Off-Target Protein That Mistakenly Harbors Erectile Dysfunction Drugs

Humans perceive vision via a specialized tissue at the back of our eye known as the retina. The retina is comprised of highly differentiated and elongated neurons stacked together to perform their function, which is the perception of light. Out of these neurons, rod photoreceptors mediate low-light vision, while cone photoreceptors perceive color vision. Both