Multi-System Morbid Disease Associated With Mutations Ostensibly Affecting Non-Protein Synthesis Activities Of A tRNA Synthetase
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Zhiwen Xu is a researcher from the Hong Kong University of Science and Technology

                       

Multi-System Morbid Disease Associated With Mutations Ostensibly Affecting Non-Protein Synthesis Activities Of A tRNA Synthetase

Aminoacyl-tRNA synthetases (aaRSs) are a family of ancient enzymes. Their primary function is to build proteins by loading up the proper amino acids to charging transfer ribonucleic acids (tRNAs). In recent decades, this protein family has been increasingly studied for non-classical functions beyond protein synthesis. In humans, this family of proteins is encoded by 37 genes, with 17 encoding the cytoplasmic aaRSs, 17 encoding the mitochondrial forms, and 3 bi-functional aaRSs functioning in both cytoplasm and mitochondria. Up until 2017,...

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