About The Author

Zhenjun Yang is a researcher affiliated with the Peking University School of Pharmaceutical Sciences.

Assembly And Transfection Of Novel Nucleobase-Lipids

In past decades, nucleic acid drugs have gained significant attention thanks to the tremendous potential for the treatment of inherited diseases. However, efficient and biocompatible delivery of nucleic acids still remains challenging. Cationic lipids can pack nucleic acids into nanoparticles via electrostatic interaction, while the cytotoxicity and possibility of negatively-charged serum proteins binding at physiological