Heme-Specific Antibodies
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About The Author

Zélia Gouevia is a researcher at the Institut Curie Subcellular Structure and Cellular Dynamics Division. Her research interests include protein expression, animal modeling, and immunology.

                       

Heme-Specific Antibodies

A healthy adult human has about 2-3x1013 red blood cells (RBC) with a hemoglobin (Hb) content of about 3.108 molecules/RBC, equivalent to ~109 heme molecules per RBC. Clinically silent intravascular hemolysis can lead to the release of relatively high levels of biologically active Hb into plasma. The prosthetic heme group of extracellular Hb can be released upon oxidation, giving rise to labile heme (1-3). When released from Hb however, heme is most probably never in a free form and instead...

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