A Novel Strategy To Enhance Immunotherapy By Interleukin 2 Tethered To Its Receptor
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About The Author

Youssef Jounaidi is an instructor in Anaesthesia and researcher at Massachusetts General Hospital. His research specializes in cancer biology. He has authored/co-authored 50+ publications and has over 1,000 citations.

                       

A Novel Strategy To Enhance Immunotherapy By Interleukin 2 Tethered To Its Receptor

Interleukin-2 a cytokine secreted by T cells has stimulating effects on T cells and natural killer (NK) cells. Systemic IL2 administration could, therefore, enhance NK-mediated immunity in a variety of diseases ranging from neoplasms to viral infection. However, its use is restricted by its serious side effects that cause pulmonary edema and mimic sepsis. Although injections of smaller doses of IL2 could be tolerated and might activate the immune system, there is, however, the potential to activate another subset of...

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