Is Dark Chemical Matter Really Dark?
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About The Author

Vishal Siramshetty is a doctoral researcher at Freie Universität Berlin. His current research work focuses on the application and development of cheminformatics methods for computational prediction of chemical activity/ toxicity and compound promiscuity assessment. Ialso focus on data mining and development of machine-learning models to address questions indrug discovery.

                       

Is Dark Chemical Matter Really Dark?

High-throughput screening (HTS) and combinatorial chemistry were introduced in the early 1990s to improve R&D productivity, which remained a daunting challenge for the pharmaceutical industry. Large libraries of chemical compounds could be tested against a panel of biological targets to identify primary hits that could be validated for confirmed biological activity and furthered into the next steps of drug discovery. A large proportion of the HTS hits is omitted in the early steps due to many reasons, one being the...

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