The Role Of DDX3X In The Immune System
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About The Author

Our research aims at understanding how the synthesis of IFN is initiated when cells or animals are infected with intracellular bacteria and how IFN give rise to changes in the cellular transcriptome. Microbial infection causes cellular signals that produce activated interferon regulatory factors (IRF), transcriptional regulators of the IFN genes. We have identified an RNA helicase, DDX3X, that enhances the ability of IRF to stimulate IFN transcription. Current activities aim at studying the importance of the DDX3X enzyme for innate immunity in cells and mice. Furthermore, we address the mechanism by which DDX3X contributes to transcriptional regulation of antimicrobial genes.

Thomas is a Professor at the University of Vienna, Faculty of Molecular Biology.

                       

The Role Of DDX3X In The Immune System

The innate immune system establishes a first-line defense against invading pathogenic microorganisms. The pathogens are sensed by dedicated antigen receptors. These receptors subsequently emit signals that reprogram cells of the immune system, preparing them for combat. Enabling cells to increase their immunological performance requires them to turn on sometimes hundreds of genes and repress others whose products are not needed. Enzymes belonging to the large family of RNA helicases function in many aspects of RNA metabolism such as processing, transport,...

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