Investigating Corneal Wound Healing From Fibrosis In Lung, Kidney, Skin And Other Organs
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About The Author

Steven E. Wilson M.D. is a practicing ophthalmologist at the Cleveland Clinic. His primary research aims are to identify and characterize the growth factor-receptor systems through which the functions of corneal, immune, and other cells of the anterior segment of the eye are controlled during development, homeostasis, and wound healing; (II) understand at the molecular and cellular level, the factors that lead to corneal opacity, and its resolution, after injury, surgery or infection.

                       

Investigating Corneal Wound Healing From Fibrosis In Lung, Kidney, Skin And Other Organs

Basement membranes likely modulate fibrosis triggered by diverse injuries in many tissues such as lung, skin, and kidney by modulating the availability and function of pro-fibrotic transforming growth factor (TGF) β, platelet-derived growth factor (PDGF), and other modulators. This concept has recently been conclusively demonstrated in the clear anterior wall of the eye called the cornea, where injury and defective regeneration of the epithelial basement membrane (EMB) trigger myofibroblast development and fibrosis (“haze,” Fig. 1) in the anterior corneal stroma....

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