Diversity-oriented Synthesis Of Oxacyclic Spirooxindole Derivatives: Useful DOS Strategy For Drug Discovery
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Satheeshkumar is a research scientist at the Indian Institute of Chemical Technology.

                       

Diversity-oriented Synthesis Of Oxacyclic Spirooxindole Derivatives: Useful DOS Strategy For Drug Discovery

In recent years, diversity-oriented synthesis (DOS) has drawn a huge interest from researchers in the vicinity of synthetic organic chemistry and medicinal chemistry because it is a powerful device to find the most structural variability from easy starting materials. Also, it is important to synthesize a variety of novel and biologically attractive small molecules in drug discovery. The spirocyclic oxindole scaffolds are significant in nature because they occur in many natural products like horsfiline, gelsemine, gelseverine, and rhynchophylline. Especially, the construction...

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