Sahil Gulati

Sahil Gulati is a Life Science Application Scientist at Gatan Inc. and a former research scientist at University of California, Irvine and Case Western Reserve University

I work on understanding the structural basis of human visual photo-transduction by using a combination of cryo-electron microscopy and X-ray crystallography. The majority of my research has been focused on modulating the activation of rhodopsin and its effector G-proteins by chemically diverse synthetic ligands. Recently, we discovered a synthetic chromophore for rhodopsin that can convert its one-way activation mechanism of a G protein-coupled receptor (GPCR) into a controlled self-renewable cycle. This discovery might help in alleviating the damage caused by several retinal degenerative diseases known to humans, including retinitis pigmentosa and Stargardt disease. Most importantly, this photocyclic behavior of rhodopsin bound with synthetic chromophores opens up several avenues for using optogenetic tools where light signals will be used to manipulate signaling in neurons.

A Look Into The Off-Target Protein That Mistakenly Harbors Erectile Dysfunction Drugs

Humans perceive vision via a specialized tissue at the back of our eye known as the retina. The retina is comprised of highly differentiated and elongated neurons stacked together to perform their function, which is the perception of light. Out […]