Differences In α-Crystallin Isomerization In The Human Eye Lens Expose New Details About Aging
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About The Author

Dr. Ryan Julian is a professor of chemistry at the University of California Riverside. He received his B.S from University of Utah in1999 and his Ph.D. from California Institute of Technology in 2003.  His areas of expertise are Analytical Chemistry, Chemical Biology, Computational Chemistry, and Physical Chemistry. His current work focuses on the development of novel applications of mass spectrometry to investigate the chemistry and biology of proteins and related biomolecules.

                       

Differences In α-Crystallin Isomerization In The Human Eye Lens Expose New Details About Aging

Proteins are susceptible to spontaneous chemical degradation that can occur on timescales ranging from hours to decades, which may explain why the half-lives for many proteins are measured in days. At the same time, protein recycling is energetically inefficient and, in many cases, implausible. This makes the existence of long-lived proteins (LLPs) inevitable. Indeed, LLPs have been detected in tissue from the brain, eyes, skin, teeth, muscle, and heart, with residence times ranging from months to entire lifetimes. Many LLPs...

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