Examining Cystine Crystallization In Cystinosis Patients
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About The Author

Experienced researcher in biomaterials and drug formulation for medical device applications and in cGMP implementation for clinical human trials.

Doctoral research has led to eight first-author publications, awards in both poster and oral presentations at conferences, and four patent applications. Doctoral research was also in tandem with the development of the start-up TearClear, which scaled-up doctoral research on preservative-free eye drop formulations.

                       

Examining Cystine Crystallization In Cystinosis Patients

Cystinosis is a genetic disease that leads to the accumulation of cystine and the formation of intracellular crystals throughout the body, including in the kidney and cornea. The crystals form inside lysosomes because of the loss of cystine efflux transporters that result in accumulation above the solubility limit, leading to crystallization. The crystals in the kidney are hexagonal, while those in the cornea are needle-shaped and likely extracellular. The cystine crystals in the cornea are predominantly located in the stroma,...

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