Nico Ghilardi

Nico Ghilardi is an Associate Director and Principal Scientist of Immunology at Genentech.

For the majority of my career, I have focused on investigating the biology of cytokines. Cytokines and their receptors represent excellent targets for pharmacological intervention, not only because they are accessible to protein therapeutics, but also because many of them have very specific biological functions and are often found to be involved in disease pathophysiology. My lab has specifically focused on IL-27, IL-23, and IL-31 over the past few years. In addition, we are interested in defining and pursuing novel small and large molecule targets for therapeutic intervention in immunological diseases.

Most recently, my lab has become interested in the interaction of commensal microbiota with the host immune system, because commensals play a vital role in “educating” the adaptive immune system. This rapidly evolving field is still in its infancy, but we believe that a better understanding of microbiota will lead to novel approaches to target human inflammatory and autoimmune diseases.

Treating Asthma With An Inhalable JAK1 Inhibitor In Preclinical Models

Asthma is the result of a complex and dysregulated immune response in which the bronchial airways become inflamed and constricted. This lead to chest tightness, wheezing, and difficulty breathing. In many cases, these symptoms can be minor and temporary, and […]