The Telomerase Gene Therapy For The Treatment Of Age-Related Diseases And Telomere Syndromes Does Not Favor Cancer Development
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Miguel is a research scientist at the Centro Nacional de Investigaciones Oncológicas, Molecular Oncology Programme.

                       

The Telomerase Gene Therapy For The Treatment Of Age-Related Diseases And Telomere Syndromes Does Not Favor Cancer Development

Telomeres are protective structures at the ends of chromosomes. They consist of tandem repeats of a DNA sequence, which in all vertebrates is TTAGGG, bound by a six-protein complex known as shelterin that exerts the protective function. Telomeres shorten every time a cell divides, and when they become critically short, this induces a persistent DNA damage response (DDR) at chromosome ends which can jeopardize cell viability. In the context of the organism, telomeres shorten as our cells divide to regenerate...

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