Hypoxic Niche, Stemness And Differentiation State In Glioblastomas
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Hypoxic Niche, Stemness And Differentiation State In Glioblastomas

Glioblastomas, or GBMs, are the most aggressive CNS tumors, they are highly infiltrative, proliferative and heterogeneous. The current therapy involves surgical resection plus radio and chemotherapy and the life expectancy is around fifteen months. The standard drug used for chemotherapy is temozolomide. GBM is often characterized by rapid growth and invasion into surrounding normal brain tissue. GBM origins are divided into 3 hypotheses: Differentiated cells suffer mutations in tumor suppressor genes and oncogenes that induce dedifferentiation and tumor development; Neural...

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