The medial temporal lobe of the brain is crucial for memory in humans and animals, and its subareas (the perirhinal and postrhinal cortices, the medial and lateral entorhinal cortices and the hippocampal subfields: CA1, CA3, DG) have been recently suggested to contribute to different aspects of memory function. Our group focuses on elucidating the specific role of these distinct areas in the encoding and the retrieval of spatial and non-spatial memory across sensory modalities. For this purpose, we use new translational (standard human recognition memory tasks adapted to animals) and standard rodent behavioural recognition memory paradigms combined to state-of-the-art molecular imaging and lesion techniques. To further study the neural substrates of memory function, we also currently develop fMRI behavioural memory paradigms in awake rats, and put together human behavioural tasks to evaluate memory deficits in patients suffering from depression and post-traumatic-stress disorders.
An intuitive model for the formation of memories (the two streams hypothesis) that has prevailed for the past decades in memory research is that what is remembered from an event (a walk to a park, a birthday party, a wedding […]