About The Author

Lea Berkhout is a research scientist at Sanquin Research.

TNF Concentrations During TNF Inhibitor Treatment Predict Anti-drug Antibody Formation

TNF is an important mediator that drives the pathogenesis of several inflammatory auto-immune diseases, including Crohn’s Disease and rheumatoid arthritis (RA). Treatment of these diseases has significantly improved since the introduction of therapeutic monoclonal antibodies that specifically target TNF (TNF inhibitors). Adalimumab is one of the five TNF inhibitors that is widely used in the