Using An Electrochemical Approach To Show That TP Binds To DNA Nucleobases
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Katarina Nemcekova currently works at the Institute of Analytical Chemistry, Slovak University of Technology in Bratislava. Katarina does research in Analytical Chemistry.

                       

Using An Electrochemical Approach To Show That TP Binds To DNA Nucleobases

Exposure of deoxyribonucleic acid to endogenous or exogenous chemical and physical agents often leads to conformational changes in DNA structure. Small inorganic and organic molecules can non-covalently interact with DNA via formation of DNA-guest complexes. A ligand fixation into DNA structure can be performed by electrostatic binding between a positively charged guest and negatively charged DNA host by binding to the major and minor groove of DNA and by intercalation, meaning the insertion of the ligand molecule between DNA base...

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