Inhibiting Ferroptosis — A New Hope For Intracerebral Hemorrhage Therapy
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About The Author

Dr. Jian Wang is an associate professor of anesthesiology and critical care medicine at the Johns Hopkins University School of Medicine. His research focuses on understanding the pathophysiology of intracerebral hemorrhage. He is also interested in translational research to identify potential therapeutic targets to treat or limit hemorrhagic brain injury. Dr. Wang is a member of the American Society for Neuroscience, the American Heart Association, the American Stroke Association, the International Society for Cerebral Blood Flow & Metabolism, and the International Stroke Society. He is on the editorial boards of the Chinese Journal of Practical Nervous Diseases and Neural Regeneration Research. Dr. Wang’s work has been recognized by the American Heart Association with a Scientist Development Award and by the Ministry of Education in China with a National Science and Technology Advancement Award.

                       

Inhibiting Ferroptosis — A New Hope For Intracerebral Hemorrhage Therapy

Strokes can be divided into two main subtypes — ischemic and hemorrhagic. Ischemic stroke is the more common type and is caused by a blockage to blood flow in the brain. Intracerebral hemorrhage (ICH) is caused by the rupture of a blood vessel and subsequent bleeding into the surrounding brain. Worldwide, ICH accounts for 15% of strokes each year and is associated with high morbidity and mortality. However, effective therapies are limited, and research into ICH lags behind that for...

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Pinocembrin: A Natural Compound For Treatment Of Acute Intracerebral Hemorrhage And Traumatic Brain Injury

In the past decades, hospital admissions for acute brain injury have continued to rise. For instance, intracerebral hemorrhage (ICH) and traumatic brain injury (TBI) are just two subtypes of acute brain injury that have increased in annual incidence without a decrease in mortality. ICH is a type of stroke in which blood accumulates in the brain after a vessel ruptures. When the fluids press against the surrounding tissue, the resulting high pressure leads to mechanical damage within the first minutes...

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(−)-Epicatechin, A Natural Flavanol Compound, Protects Against Acute Brain Injuries 

(−)-Epicatechin (EC) is a natural flavanol compound found at high concentrations in green tea and cocoa.1 Recently, we and others reported that EC treatment was beneficial in animal models of ischemic stroke (caused by a blocked brain blood vessel),2 hemorrhagic stroke (caused by a burst brain blood vessel),3 and traumatic brain injury (TBI).4 EC has been shown to protect nerve cells, or neurons, in a variety of acute and chronic brain disease models. Studies indicate that EC provides these benefits...

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