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Jeremy A. O’Sullivan

My lab focuses on the regulation of immune responses, especially those involving eosinophils, mast cells, and basophils including asthma, allergic diseases, and systemic mastocytosis, by members of the siglec family of cell-surface receptors as well as the use of these receptors as therapeutic targets through which to deliver agents selectively to these cell types.

Using Siglec-8 Endocytic Mechanisms To Target Human Eosinophils And Malignant Mast Cells

Pharmacological selectivity remains a critical goal in medicine. Most drugs act on a number of molecular targets and are also delivered equally well to cells involved in the illness and those that are innocent bystanders, consequently exerting both desired and […]