About The Author

Jeannie T. Lee is a Professor of Genetics and Pathology at Harvard Medical School and the Massachusetts General Hospital, and a Howard Hughes Medical Institute Investigator. She is known for her work on X-chromosome inactivation and for discovering the functions of a new class of epigenetic regulators known as long noncoding RNAs (lncRNAs) for example Xist and Tsix.

The Inactive X Chromosome Is Folded Like Origami By SMCHD1

The linear molecules of DNA that constitute our genome are wrapped around proteins called histones to form “chromatin.” To fit the nucleus, chromatin must be neatly packaged into organized structures. For instance, mammalian chromosomes are folded into two “compartments” – an active A compartment that contains actively transcribed genes, and an inactive B compartment that