Emollient Use And Dermatitis In Children Linked To Increased Phthalate And Paraben Exposure
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About The Author

Jacob P Thyssen is a consultant at the Copenhagen University Hospital Herlev-Gentofte · Department of Dermatology and Allergology.
                       

Emollient Use And Dermatitis In Children Linked To Increased Phthalate And Paraben Exposure

Atopic dermatitis is a chronic inflammatory skin condition that primarily begins in early childhood. The skin in atopic dermatitis is characterized by immune dysfunction and by an impaired skin barrier function with a reduction of filaggrin proteins. Intracellular filaggrin proteins are degraded into amino acids and constitute a part of the so-called ‘natural moisturizing factors’, which help to maintain skin hydration. Thus, a deficiency of epidermal filaggrin results in xerotic skin with increased transepidermal water loss and increased pH, as...

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