An Application Of Rhodium Catalyst In Directed C-H Functionalization Of Quinoline N-Oxides
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Hong Liu is a researcher affiliated with Chongqing Municipal Academy of Chinese Materia Medica.

                       

An Application Of Rhodium Catalyst In Directed C-H Functionalization Of Quinoline N-Oxides

Over the past few decades, transition-metal-catalyzed C−H functionalization has emerged as a powerful strategy to synthesize complex molecules. The development of direct methods for activating the inactive C-H bonds to generate C-C bonds is more attractive but challenging due to the higher bond dissociation energy (BDE). Nevertheless, how to control the regioselectivity if the substrates have more than one reacting C−H bond remains a challenge. Therefore, the chelation-assisted transformation has become a common and powerful method for the regioselective functionalization...

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