From Magic Bullet To Magic Pump Gun: Multi-targeting Drugs For Neurodegenerative Diseases
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Holger is affiliated with the Heinrich-Heine-Universität Düsseldorf Institute of Pharmaceutical and Medicinal Chemistry.

                       

From Magic Bullet To Magic Pump Gun: Multi-targeting Drugs For Neurodegenerative Diseases

Neurodegenerative diseases are characterized by complex and multifactorial mechanisms, which are not completely understood. In particular, the molecular causes of many neurodegenerative diseases have not been identified, but numerous factors contributing to progress of disease. Alzheimer's or Parkinson's disease are the two most important representatives with high medical need for new medical entities. Despite identification of numerous biochemical targets for potential drug therapy of neurodegenerative diseases, sufficient medicinal therapies are still missing. Instead of having one target to be addressed,...

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Another Piece Of Puzzle In Adjuvant Treatment Of Inflammatory Diseases With Natural Compounds

Plants and spices are traditionally used as natural remedies. Many well established therapeutic agents are plant extracts or based on natural compounds. In which way can traditionally used plants or natural products meet the therapeutic criteria for efficacy, safety, and quality that are mandatory for clinically used, evidence-based drugs? Curcuma longa L. is used in traditional medicine of many cultures (traditional Chinese medicine, Indonesian jamu) and strongly investigated for a variety of diseases. Typical and highly heterogeneous application fields include...

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