A Closer Look at RIPK1-RIPK3 Core Amyloids
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About The Author

Hao Wu is a Chinese American biochemist and crystallographer and the Asa and Patricia Springer Professor of Structural Biology in the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School.[1] Her work focuses on molecular mechanisms of signal transduction in cell death and inflammation. She is the discoverer of signalosomes, which are large macromolecular complexes involved in cell death and in innate and adaptive immune pathways. She has established a new paradigm for signal transduction that involves higher-order protein assemblies. She has received the Pew Scholar Award, the Rita Allen Scholar Award, the Margaret Dayhoff Memorial Award, the NYC Mayor's Award for Excellence in Science and Technology, NIH MERIT and Pioneer Awards, and the Purdue University Distinguished Science Alumni Award. She was elected AAAS fellow in 2013 and to the National Academy of Sciences in 2015

                       

A Closer Look at RIPK1-RIPK3 Core Amyloids

Amyloids are fibrillar proteinaceous assemblies whose accumulation is a hallmark of several human diseases. Formation of amyloid fibrils occurs when protein monomers change their structure and clump together. This kind of irreversible polymerization can lead to the accumulation and propagation of toxic oligomeric seeds. Such accumulation of amyloid fibrils takes place in more than 20 distinct diseases, including Alzheimer’s disease and type II diabetes. Conversely, the last decade has witnessed the discovery of a second class of amyloids that are...

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