Nucleoli Identified As Potential Markers Of Aging
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The female reproductive system is the first to age in the human body and will affect every single woman. Reproductive aging is characterized by a noticeable decline in egg quantity and quality beginning in women when they reach their mid-thirties and continuing until menopause. Female reproductive aging has significant health consequences as it results in endocrine function loss and is a leading cause of infertility, miscarriages, and birth defects. Reproductive aging has a large societal impact as women globally are delaying childbearing and many women of advanced reproductive age rely on Assisted Reproductive Technologies (ART) to conceive.

The Duncan Lab uses mammalian model systems (mouse, bovine, and human) to investigate the overarching hypothesis that deterioration of oocyte-intrinsic cellular pathways together with alterations in the ovarian environment underlie the age-associated decline in female gamete quantity and quality. Our research will improve the fertile-span and health-span across generations through discovery of novel cellular pathways for therapeutic interventions.

                       

Nucleoli Identified As Potential Markers Of Aging

Female reproductive aging is a major issue in today’s modern society. More and more women are choosing to delay childbearing for reasons that vary from effective contraception, increased presence in the workforce, and changes in values and family structures. However, the female reproductive system is the first to age in the human body, and it is characterized by a loss of gamete (oocyte) quantity and quality that begins already when women reach their mid-thirties. Reproductive aging can lead to infertility...

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