About The Author

Fernanda is a research scientist at the University of São Paulo.

Admixed Populations: How To Correct For Ancestry Bias In Genetic Association Studies

Admixed populations pose a special challenge in genetic association studies due to the different proportions of a contribution of two or more ancestries. In the classic design of case-control studies, allele frequencies between disease and healthy subjects are compared; however, spurious associations not related to causative loci can be obtained by unmeasured population substructure. The