Scientists Just Reprogrammed Malignant Melanoma Cancer Cells Into Less Aggressive Cancer Cells
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Diana Câmara is a PhD student at the Universidade Federal de São Paulo | UNIFESP · Functional and Structural Biology.

                       

Scientists Just Reprogrammed Malignant Melanoma Cancer Cells Into Less Aggressive Cancer Cells

Malignant melanoma is a heterogeneous tumor, originated from the transformation of melanocytes, which are cells that normally produce melanin in the skin and distribute to neighboring cells. However, unlike melanocytes, melanoma cells do not secrete the pigment, which is stored in the cytoplasm in organelles called melanosomes, conferring the hyperpigmentation characteristic of melanomas. The heterogeneity is a characteristic of melanomas, due to genetic and epigenetic mutations that modify cell proliferation, differentiation, and cell death. Indeed, it is postulated that melanomagenesis...

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