Sickle Cells Direct Cytotoxics And Oncolytic Virus To Hypoxic Tumor Niches And Induce A Tumoricidal Response
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David S. Terman is a researcher affiliated with the University of Alabama at Birmingham.

                       

Sickle Cells Direct Cytotoxics And Oncolytic Virus To Hypoxic Tumor Niches And Induce A Tumoricidal Response

Sickle erythrocytes are a unique mammalian erythroid lineage that under hypoxic conditions alter their shape becoming rigid and adherent to blood vessels resulting in vaso-occlusion.  We reasoned that this property could make them useful for targeting and arresting the growth of oxygen-starved tumor cells. Such tumor cell niches constitute a major cause of resistance to treatment with chemotherapy and radiation. Using hyperspectral imaging and intravital microscopy in a mouse model of triple negative breast cancer we showed that human sickle...

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