About The Author

We use basic and translational approaches in the mouse to investigate the development, regeneration and repair of the musculoskeletal system.  A key component of our research program is the use of genome modification technologies to understand fundamental cell biological processes at the genetic and molecular levels.  Current areas of interest include the following:

  • Regulatory circuitry controlling muscle-resident stem cell programming and differentiation in regenerating muscle and in muscular dystrophies
  • Stem cell therapeutics for repair of muscle and bone
  • Embryological origins of muscle stem cells
  • Pathophysiology of heterotopic ossification, with a focus on the early initiating events following injury and in fibrodysplasia ossificans progressiva (FOP)
  • Muscle-bone interactions in early development
  • Transcriptional regulation of muscle regulatory genes in muscle development and regeneration

Scientists Discover Cells Responsible For Stone Man Syndrome

Scientists at the University of Connecticut recently published work in Nature Communications (Lees-Shepard et al. 2018, NatComms 9, 471) that describes the discovery of the cell type that is responsible for fibrodysplasia ossificans progressiva (FOP), a rare genetic disease in which skeletal muscle tissue and connective tissues, such as tendons and ligaments, are gradually replaced