Fighting Histoplasma Capsulatum Infection With IFN-γ Macrophage Activation
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About The Author

Chad Rappleye is an Associate Professor, Microbial Infection and Immunity at Ohio State University. Dr. Rappleye's laboratory studies the mechanisms that underlie the virulence of fungal pathogens. The majority of our efforts are directed at understanding Histoplasma capsulatum, the causative agent of histoplasmosis. We are using molecular approaches to discover the factors that facilitate Histoplasma pathogenesis and are determining their role using in vitro and animal infection models. In addition we are screening chemical libraries and using forward genetics to identify potential drugs and drug targets that could be exploited to improve outcomes for fungal disease.


Fighting Histoplasma Capsulatum Infection With IFN-γ Macrophage Activation

Unlike opportunistic fungal pathogens, Histoplasma capsulatum can infect and cause disease in otherwise healthy individuals. Infections result from inhalation of infectious fungal conidia (spores) following disturbance of soils where it grows as a mycelium. In the lung, exposure to the mammalian body temperature triggers the conidia to convert into pathogenic yeast cells which invade phagocytic cells of the immune system. Normally, these phagocytic cells are adept at eliminating fungal invaders, but H. capsulatum yeasts are able to survive and proliferate...

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