Editor's Pick Featured Share Your Research

Catherine Wu

Research in the Wu Lab focuses on how best to effectively mount human immune responses to recognize and eradicate cancer, with dedicated effort on the discovery and targeting of tumor antigens. A longstanding theme of our studies has been how best to launch immunotherapeutic efforts in a personalized fashion, initially through studies in the area of hematopoietic stem cell transplantation (HSCT), together with whole tumor cell vaccination (Burkhardt JCI 2013), and more recently through the implementation of personal neoantigen-targeting cancer vaccines (Ott & Hu Nature 2017; NCT 01970358).

Key to our antigen discovery efforts has been our pioneering of approaches to leverage the recent availability of next-generation massively parallel sequencing technologies to perform comprehensive genomic dissection of leukemia cells. Our efforts have led to the discovery of key mutated genes and pathways involved in the pathogenesis of chronic lymphocytic leukemia (CLL) (N Engl J Med, 2011), understanding of the vast clonal heterogeneity of leukemia samples and its impact on clonal evolution (Cell, 2013; Cancer Cell 2014), and the development of resistance to therapy (Nature 2015, Nat Comm 2016).

We have further leveraged these sequencing technologies to pioneer computational tools for the comprehensive discovery of potential personal tumor-specific neoantigens (Blood 2014; Nat Biotech 2015). Neoantigens are a promising novel class of cancer targets created by the personal mutations found in each patient’s tumor. Because these mutations generate peptides that are distinct from “self”-peptides, the resulting epitopes are expected to escape the immune dampening effects of central tolerance.

A Novel Approach To Identify Genetic Signatures Of Clinical Outcome To Ipilimumab

Immune therapies focused on unleashing the body’s own immune system against cancer have heralded a revolution in clinical oncology. Dramatic responses are now being observed in several intractable tumor types like metastatic melanomas which were previously associated with very short […]