About The Author

The Metabolic Inquiry and Cellular Engineering (MICE) Lab, uses systems approaches (both experimental and computational) to understand biological cell behavior and function. We build computer models of the cell through genome-scale metabolic network reconstruction and compute cell phenotype using constraints-based flux balance analysis. We are also involved in building metabolic reconstructions using QC/QA protocols and algorithms for incorporating experimental data as constraints. Experimental approaches in prokaryotes involve genome-engineering of Escherichia coli for value added chemicals using recombinant and synthetic biology techniques. The spectrum of products we are interested in range from drug molecules like violacein, non ribosomal peptides like penicillin and biopolymers like polyhydroxyalkanoates.

Death Of The Superbug: Using Computer Models To Identify Mechanisms And Targetable Vulnerabilities

Published by Anu Raghunathan Chemical Engineering Division, CSIR-National Chemical Laboratory, Pune, Maharashtra, India These findings are described in the article entitled Constraints-based analysis identifies NAD+ recycling through metabolic reprogramming in antibiotic resistant Chromobacterium violaceum, recently published in the journal PLoS One (PLoS ONE 14(1): e0210008). This work was conducted by Deepanwita Banerjee and Anu Raghunathan