Improving Clinical Outcomes For Second Hematopoietic Stem Cell Transplants For Thalassemia Major
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About The Author

Anu is an associate professor at the Christian Medical College in Vellore, India. Anu's research interests include diagnosis and stem cell transplant in Primary immune deficiency disorders and the biology and management of lymphoma.

                       

Improving Clinical Outcomes For Second Hematopoietic Stem Cell Transplants For Thalassemia Major

Allogeneic stem cell transplant is the only cure for β Thalassemia Major, but even with a matched sibling donor transplant, graft rejection is an unfortunate but all-too-common complication that may occur in up to 30% of transplants. This is especially true among patients older than 7 years of age and those with inadequate pre-transplant supportive care. Inadequate blood transfusions and sub-optimal iron chelation therapy can lead to iron overload-related end-organ damage. The liver is one the organs that is affected...

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