Admixed Populations: How To Correct For Ancestry Bias In Genetic Association Studies
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Aguinaldo is a research scientist at the University of São Paulo, Departamento de Genética (Ribeirão Preto).

                       

Admixed Populations: How To Correct For Ancestry Bias In Genetic Association Studies

Admixed populations pose a special challenge in genetic association studies due to the different proportions of a contribution of two or more ancestries. In the classic design of case-control studies, allele frequencies between disease and healthy subjects are compared; however, spurious associations not related to causative loci can be obtained by unmeasured population substructure. The issue of unobserved confounding effects appears when the investigated population is composed of several ancestral subpopulations with different allele frequencies and disease-risk not equally represented...

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