Considerations For Designing Vaccine Trials During Epidemics
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About The Author

Rebecca Kahn is a doctoral student at the Harvard T.H. Chan School of Public Health. She earned her MS in Epidemiology from Harvard University in 2018. After graduating with a BA in Public Policy and Global Health from Duke University, she worked with the President’s Emergency Plan for AIDS Relief (PEPFAR) in the U.S. State Department’s Office of the Global AIDS Coordinator (OGAC). Her current research focuses on using simulation and disease transmission models to aid in the design of vaccine trials for emerging infections.


Considerations For Designing Vaccine Trials During Epidemics

During the 2014-2016 Ebola epidemic, incredible efforts were made to quickly develop a vaccine for this deadly disease. However, once the vaccine was ready for testing at a large scale, debate ensued around the best way to design a trial to evaluate this investigational vaccine in an emergency setting. In our recent article in PLoS Medicine, Choices in vaccine trial design in epidemics of emerging infections, we summarize considerations for designing vaccine trials during epidemics. We focus on four choices...

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